"There is no one left. The test shows that the maximum drug tolerance of a 20g mouse is 0.08g. Based on this, it is estimated that the maximum drug tolerance of a 50kg adult is 200g. Of course, this is only experimental data. Obviously, it is impossible to draw accurate experimental conclusions with mice."
Li Zheng took the experiment notebook handed over by Kent and quickly browsed it.
The progress of the experiment was smooth, and the "taxane" was successfully replicated. However, the drug toxicity of taxane was much higher than Li Zheng remembered.
0.08 grams of the drug, even after being diluted with a large amount of normal saline, still caused the mice to experience violent convulsions, vomiting, and fur fall.
Fifty mice, without exception, lost their basic mobility. However, what is exciting is that there is indeed no active Dok virus in the blood samples of the mice treated with taxane.
"It's really amazing, ignoring its poor vital signs data, yclone did kill the virus." Kent looked at the blood sample results and couldn't help but be amazed.
However, there was no trace of relief on Li Zheng's face.
"According to such data, if the drug is used on people, out of ten patients will not necessarily survive five. The five who survive will also have a long recovery period, and even some sequelae will be lifelong."
Li Zheng couldn't help but think of the boy they rescued at the border when they first came to Doman, and the indifferent words of the big black man. People who have lost their labor and need long-term care will not live long in Africa.
"Inform the Doman military that I need ten cats of the same breed and similar weight." Cats have similar reflex functions, developed circulatory and nervous systems, and are most suitable for observing drug reactions.
The general Dorman came back the day after the helicopter incident. He had the hospital be surrounded by people, under the pretense of creating a good experimental environment for Li Zheng, but anyone with a discerning eye could see that this It is house arrest in disguise.
However, he was very cooperative with the experimental matters, but within two hours, three or four pickups were parked downstairs in the temporary hospital.
A dozen Doman soldiers carefully removed a dozen cages from the back of the truck, and Kent watched in awe as the soldiers moved the caged animals to the open space behind the laboratory.
"This, this... is this a cat?"
I saw the organism in the cage was about 100 centimeters long, with a sandy yellow body covered with black spots, and looked like a small cheetah from a distance.
Is this a cat? Everyone looked at each other.
"Mr. Li, in our current situation, we cannot find ten cats that meet your requirements in a short period of time. These were intercepted by our defenders at the border. I think they look similar to cats, and they should also be cats. I don't know if it will work."
Serval
Li Zheng recognized this rare and famous animal the moment the cage was unloaded from the truck. It was included in the "Convention on International Trade in Endangered Species of Wild Fauna and Flora" due to excessive poaching for its beautiful fur.
How much does a pet serval cost? 200,000
"It's troublesome, it can be used." Li Zheng rubbed his temples with some headache, and gave a positive answer in the slightly nervous eyes of the Doman soldier.
"Test the vital signs. If there is no problem, start the second round of experiments." Li Zheng said.
Three months is enough time for a lot of things to happen. For example, the martial arts film starring Zhou Sitian was introduced to the mainland, and its screen image was regarded as a goddess by many young men; another example was the Xiangjiang garrison incident in May 1984, which was seen by the world. China's determination to take back Hong Kong.
Another example is that the United Nations medical support team headed by Li Zheng was besieged in Dorman, and the global biopharmaceutical community united to put pressure on Washington and the United Nations Building, so that the eyes of people all over the world fell on this African land.
On this day, the police force around the hospital tripled, and two types of soldiers in different uniforms occupied one side of the hospital.
"I didn't expect that we would still have the opportunity to sit together and communicate peacefully." The officer's clothes knew that it was not from the government's side.
"We never initiated a war." The black general looked at his opponent coldly.
Yes, the two parties are the Doman government and the opposition.
Dok disease is a national disease. On today's special day, even the greatest hatred and differences between Doman people must be put aside first.
Around 9:00 in the morning, buses with the flags of the United Nations garrison stopped in front of the temporary hospital, and countless reporters got off the buses carrying long guns and short cannons.
That General Dorman's face was a bit ugly. He knew that this time, no matter if Li Zheng had developed a drug to treat Doke's disease as promised, he would not be able to keep this Mr. Li.
"Lee, are you a little nervous? I have only seen such a scene during the presidential election." Kent looked out the window and couldn't help but marvel at the dense number of soldiers and reporters below.
Li Zheng's hand hanging by his side clenched unconsciously, he let out a sigh of turbidity, "Well, it's a little bit." Even if the two lifetimes add up, this is the biggest scene Li Zheng has ever seen.
The crowd outside the window rioted, and the two trains slowly drove towards the hospital. One team had the Doman flag on it, and the other team had the flag of the opposition.
"It's President Doman and the leader of the opposition. They came together!" a reporter exclaimed.
The reporter, who was still trying to squeeze in, turned the front of the train and rushed in the direction of the two trains.
Dorman's two most powerful people got out of their respective cars. President Doman is older and wears traditional Doman attire, while the opposition leader is younger and wears a straight western suit. This also represents two different governance concepts.
"Mr. President, you and the leaders of the opposition appear on the same occasion, does it mean that the two sides have a chance to coexist peacefully?"
"Mr. Munch, it is generally believed that this war was deliberately provoked by the opposition. Do you have any disagreement with this statement?"
…
A word or two of Doman vernacular was mixed in the messy English.
Mr. President walked inside under the escort of the guards. Seeing that these reporters were too persistent, he stopped at the right time.
Under the flattered gaze of a certain reporter, he took his microphone.
"Disease and war are the most acute contradictions in Doman today. If Mr. Li Zheng can really help the people of Doman to get out of the nightmare of disease, then I promise here that I will work hard to find a way to peace." Mr. President is serious said.
"Mr. Munch, what are your thoughts?"
Munch glanced at President Doman, pursed his lips and said, "Health and peace have always been the dream pursued by the people of Doman, as well as my childhood dream."
Ka Ka Ka Ka Ka Ka, the flashing lights sounded.
All the reporters were excited, and it was almost a peace declaration from Doman. if only! if only! That Mr. Li Zheng's medicine can really come out smoothly!
"This is a declaration of peace between the two sides!"
"Mr. President, Mr. Monchi, please answer one more question."
"Mr. President! Mr. Monchi!"
"I can only say, I am very grateful for this opportunity, Mr. Monchi and I can sit down and have a good understanding of each other's thoughts."
Witness a nation's declaration of peace! What an exciting historical moment! Not only the reporters present, but the motionless Doman soldiers standing beside them also had a strange light in their eyes, and many of them even secretly blushed.
They, who were numbly beaten by wars, saw hope today!
As long as the drug can be successfully launched! As long as the drug can be successfully launched! Two things that are clearly irrelevant, but at this time there seems to be a causal logical relationship, and everyone pinned their hopes on this Chinese biologist.
The sound insulation effect of the composite board is really not very good, Li Zheng can clearly hear the answer from the president, Mr. Monchi and the reporters outside.
There was a wry smile on his face, and he became Doman's hope of peace in a daze.
Now both sides have the meaning of a truce, there is only one opportunity left, and he is the best opportunity. A little bit of pressure.
"Mr. Li Zheng, it's time for you to go out." Dr. Kaqi knocked on the door, and his expression was very excited. He has been helping in the laboratory for the past three months, and he naturally knows the progress of the test. He has a hunch that this It will be a turning point in his life!
"I see." Li Zheng nodded with a smile.
Kent Blair took care of his leader and stared at the glass on the biological cabinet for a while before getting up satisfied.
"Let's go." He said with a smile.
Li Zheng laughed dumbly. He reconfirmed the information in his hand, but he accidentally knocked over the paper cup next to him when he was about to get up.
He hurriedly took out a paper towel to dry the water.
It's okay, the data is all right.
At this moment, an unfamiliar inspection report came into Li Zheng's eyes.
Serval blood test results
The ten servals were used by Li Zheng to observe the drug reaction of taxane. During those three months, he and Kent spent most of their time reducing drug toxicity, easing drug reactions and reducing patient suffering.
Because there are examples of carbapenem antibiotics, and Li Zheng's memory of his previous life, the progress of the two is quite smooth. Although the toxicity of the drug is still impossible to pass the international standard, it is at least within the acceptable range of the human body. .
After reaching their goal, the two put the serval aside without paying too much attention.
While doing the drug reaction test, he had told members of the helping medical team that the serval would be tested daily for blood.
The member of the medical team persevered diligently, but Li Zheng never paid attention to the data in the days after the drug reaction test.
However, when he looked at it today, he could see that it was unusual.
"Where's the ten servals! Immediately! Immediately! Re-measure their blood samples for me! Teams of two! Make sure the data is correct!" Li Zheng shouted.
Everyone, including Kent, was taken aback.
"The serval has moved to the backyard! But Mr. Li, now Mr. President, Mr. Monchi and reporters from all over the world are waiting, you..." Kachi said cautiously, and he couldn't help but feel uneasy. There's nothing wrong with this experiment.
"I don't understand human language! I said, immediately! Immediately!" Li Zheng felt that his heart had never beat so fast before, all the blood in his body rushed into his brain, and an unprecedented excitement appeared in the On him, he felt that the breath exhaled from his nose was hot!
"Lee..." Kent's brows furrowed tightly.
"Blair, look at these indicators!" Li Zheng swept his right hand and swept all the experimental materials to the ground. He put the test results of the serval blood samples on the table one by one, and then took the blank paper.
"Look, these, and these, these indicators are turned into a line chart with the date as the horizontal axis and the indicator value as the number axis. Did you see it!" Li Zheng's voice trembled slightly.
Kent heard the words, leaned his head, and immediately took a breath of cold air!
"This, this... Impossible, how is it possible! Taxane can only kill active viruses, this indicator..." Kent's mouth stuttered a little because of excitement.