After Zhao Depei hung up the phone, he was stunned. He could understand every word Li Zheng said, but why couldn't he understand when they were connected together
What is it, it is still possible to leave a place for Huaguo. If you are watching a movie in a cinema, you can still reserve a place for others.
What other experiments, and what experiments have produced results, can stop the debate in the scientific research community in the United States, and greatly promote the advancement of the Human Genome Project? Why didn't he hear the slightest bit of wind
"Zhao... Principal Zhao?" Sun Bin said cautiously. His heart was very uncomfortable. He was only halfway through talking with Professor Li. Professor Li can say that each of them can have an independent signature. SCI papers!
Those were SCI papers, and now the Huaqing campus has published SCI papers, and he can count them by hand. He can already imagine the envious, jealous eyes of his classmates after he published the paper.
It's just that this achievement is related to patents. He is not sure what can be written and what can't be written. Principal Zhao, you should take your hand away from the telephone.
"Huh?" Zhao Depei suddenly recovered from his thoughts. He saw Sun Bin who was looking at him carefully, and pursed his lips. Chen Anbang and those seniors in the Chinese biosphere.
"Do things well." Zhao Depei patted Sun Bin on the shoulder, and walked out of the laboratory with a confused expression on Sun Bin's face. What he has to do now is to first write down the so-called leave note. find out!
Meng Jie and Lu Keke approached Sun Bin.
"School... Principal, no... are you okay?" After entering the ninth laboratory, Meng Jie became more confident and even more talkative because of his ability in biological research.
"It's okay, what can the principal do! Sun Bin, did Professor Li just let us write our own thesis?" He Lu Keke stared at Sun Bin with burning eyes.
Sun Bin glanced at him, "The ears are really pointy. That's right, that's what the professor meant. This project of organ storage indefinitely has been called one of the tickets for the future medical industry by the Western media, and it has attracted a lot of attention. Project papers must be published in top international journals such as "Science" and "Cell", although we are only responsible for a small part of the experiment, but if this small part is written as an academic paper, the threshold for SCI papers can still be reached."
Lu Keke let out a burst of cheers, "I feel like I'm in a dream!"
On the other side, Zhao Depei returned to the office, rummaged through the boxes, and finally found the leave request slip from Li Zheng's mouth.
Person asking for leave: Li Zheng
Date of leave: May 25, 1986 to June 18, 1986
Reason for leave: Going to a biology conference on Long Island, New York
Going to a biology conference on Long Island, NY? !
The Cold Spring Harbor Laboratory is indeed on Long Island, New York. That's right, it's okay for the Human Genome Project experts to meet and say it's a biology conference! But can't you write more clearly! !
Zhao Depei clutched his chest and almost spat out a mouthful of old blood.
"Xiao Chen, come over here." He called Chen Anbang.
When Chen Anbang knocked on the door and came in, Zhao Depei was still in a daze with the leave slip.
"headmaster."
"Well, sit down." Zhao Depei said, handing the slip in his hand to Chen Anbang, "Look, this is the slip that Li Zheng used to ask me for leave after the Huaqing Award establishment ceremony."
Chen Anbang was at a loss. He was so busy these days that Mr. Meng left. As Mr. Meng's disciple, he received the network resources in front of Mr. Meng. The Human Genome Project was like dripping oil in a pot of boiling oil. The water inside made the entire Huaguo biological community agitated. Recently, he was busy using the contacts in front of Mr. Meng to make the Huaguo biological community make his voice heard internationally.
At this time, Zhao Depei came to him to see the leave request
Chen Anbang has a good temper. Zhao Depei asked him to watch it, and he just watched it. At this glance, he could see that the doorway was coming, the Long Island Biology Conference in early June.
"Human Genome Expert Meeting?!" Chen Anbang stood up abruptly, his voice slightly high in surprise.
"Well, that's right." How could Chen Anbang see it at a glance, Zhao Depei muttered in his heart, this is not his fault, he is not in the biological circle, he is not that sensitive.
"Li Zheng attended the Human Genome Expert Meeting? What did he say? Did you tell him what we meant?" Chen Anbang looked at Zhao Depei nervously, clutching the fake note tightly in his hand, clenching its corners. Extremely wrinkled.
"He, he said that now is not a good time for Hua Guo to participate in the Human Genome Project..." Zhao Depei repeated Li Zheng's words to Chen Anbang.
After Chen Angang heard it, he was speechless for a long time. After a long time, he stood up and said, "This is not something I can decide. I have to discuss it with them."
Not to mention the fact that the biologists in China had been arguing for half a month after hearing the news, Li Zheng and Ruiz finally found a suspected target a month later.
EGFR
"Mutations are concentrated in exons 18-21 of the EGFR kinase region. The main mutation situation is the exon sequence of EGFR. 18 mutation G719, etc.; 19 deletions 15BP, 19BP, 12BP, 9BP; 20, T790M insertion; 21 mutation L85SR, etc.. According to In 500 sets of comparative experiments, the incidences of mutations 18, 19, 20, and 21 were 5%, 45%, 5%, and 45%, respectively. The report is over!" Richard exclaimed.
Ruiz quickly grabbed the data analysis report in Richard's hand, "Lee, I have a hunch, this must be what we are looking for!" He said excitedly.
Of course Li Zheng knew that EGRF was the target they were looking for.
The choice of this target was carefully considered by Li Zheng. He is one of the most obvious and easily discovered targets under the current conditions. At the same time, this mutation is commonly found in Asians and non-smokers, and Asian patients are as high as 60%, which is the most important purpose he took the lead in launching this project.
"Obviously, the deletion of exon 19 and the mutation L858R in exon 21 are the two most common EGFR mutations. We are responsible for one of them, and we meet every two days to share information, okay?" Li Zheng said solemnly. said.
Ruiz nodded vigorously, "Okay, my friend, let's start right away!"
Once the target is found and the corresponding inhibitor is studied, there is a direction. Both are experts in anti-tumor drug research. Ruiz has studied lung cancer drugs for half his life, and Li Zheng stands on the shoulders of giants.
In early 1987, the U.S. Department of Energy and the National Institutes of Medicine allocated $550 as start-up funding for the Human Genome Project, and announced the start of preparations for the laboratory.
Just the day after the U.S. Department of Energy and the National Academy of Sciences announced the decision, the type 1 human epidermal growth factor receptor in Ruiz's laboratory passed a difficult biological experiment and officially entered the clinical stage!
"I got in touch with the state hospital. In just one week, 120 patients have signed up. They are all advanced lung cancer patients, and many of them can no longer go to the ground." Ruiz handed the registration materials to Li Zheng.
After working together for half a year, the two had already reached a certain tacit understanding. Li Zheng flipped through the pages a little and said, "Choose sixty, and divide them into three steps for clinical comparison according to the severity of the disease."
After the clinical results of late-stage patients come out, it will be decided whether to conduct clinical trials in mid-stage or even early-stage patients.
"Well, okay." Ruiz nodded.
He put down the information in his hand, with a tangled look on his face, he looked at Li Zheng and hesitated, and finally couldn't help but ask.
"Li, have you participated in the whole process of drug clinical practice? I mean not only clinical data analysis, but field participation."
Participate in the whole process of clinical medicine? There doesn't seem to be any.
When he was using pamidosatine, he deliberately asked an Indian manufacturer to do human clinical trials. When he was on yclone, his nerves were tense every day because of the situation in Doman. The Doman army was intrigued and did not have time to participate in the whole process.
The most involved drug clinical trial for humans was probably the drug clinical trial of carbapenem antibiotics, because there was only one drug experimenter at that time, who was his respected teacher.
As for the previous life, third-party outsourcing has developed very well, and drug researchers only need to visit occasionally, and except for special circumstances, there is no need to participate in the whole process.
Seeing Li Zheng's silence, Ruiz understood his answer, "Li, you are amazing, your academic level is very high, especially your experimental ideas, clear logic and clear direction, you are an amazing scientist. But after all, you are still young, If you can't stand the next clinical trial, please tell me at any time, we are friends." Ruiz said solemnly.
Li Zheng didn't understand Ruiz's meaning at first, but as the project team entered the state hospital and looked at the patients who were lying on the bed almost like they were not alive, Li Zheng couldn't help but understand a little.
However, in his opinion, Ruiz really underestimated him. As a biopharmaceutical person, this is something that must be experienced.
"Professor Ruiz, Professor Li, all 60 applicants are here. They and their families have signed a clinical drug agreement. This is their case." The doctor from the state hospital handed a stack of cases to the two of them. .
Ruiz nodded, "I see."
Zhouli Hospital has opened up an entire floor as a clinical trial base for this drug, one room for every two patients. Sixty patients are divided into three steps according to their condition, and the best ones can stand up and walk for a while.
In the middle, you can walk for a while with the help of others.
The worst was lying on the hospital bed. I heard that even touching it hurts a lot.