Li Zheng made an appointment with Yang Lao the day after he returned from Jinjiang.
"When is Professor Li free to make an appointment with this old man? Let's talk about it first, I'm retired, don't ask me for things like slamming the table with the leader." As soon as Yang Lao walked into Li Zheng's laboratory, he smiled. He hehe took out a blue leather retirement card and shook it in front of him.
Li Zheng touched his nose, got up and made a cup of tea for Yang Lao himself, "Yang Lao, in your eyes, I am such a person."
"No, you can go to the Three Treasures Hall for everything." Old Yang didn't give Li Zheng any face.
Li Zheng…
However, what Yang Lao said was right. He invited people to come over, and it really happened.
"I hope that the HPV virus vaccine will be clinically administered for the first time in China."
Yang Laocha drank half, a mouthful of tea stuck in his throat, and a cough burst out instantly.
He coughed for a while, and said dryly, "Oh, this is a good thing, a good thing."
Promoting the clinical work of HPV virus vaccine and promoting the reform of the national drug approval system are two different things. The latter has many drawbacks and must be corrected. For the former, Mr. Yang has also read a paper on the carcinogenicity of HPV, and still holds the connection between HPV and cervical cancer. Doubtful.
It is good to say that the clinical trial is successful. If something goes wrong, this is a vaccine clinical trial after all, which means that the volunteers are not dying patients, but healthy people. After the healthy people are injected with the vaccine, they are immediately exposed to the virus to observe the effect of the vaccine. If you don't get this one right, you will be criticized by the population.
Yang Lao also knows that if the vaccine is successfully developed, this anti-cancer vaccine will bring great prestige and glory to China just like the previous hepatitis B vaccine. Don't like risk.
Li Zheng could see the embarrassment on Mr. Yang's face, and he sighed in his heart, "Elder Yang, I am not asking you to support me, but I hope to hold a drug review committee meeting in your name, and give me at least one. An opportunity to present to your seniors."
The drug review committee meeting, equivalent to the highest authority of the drug administration department, once a month, focuses on the difficult drug approval issues in January. Although Yang Lao and others have retired from their positions, they are still participating in January A drug review meeting.
It's just that this drug review meeting is usually scheduled and held in the drug control building. Apart from a group of experts, there are also officials from the drug control department. It is the nature of officials to be conservative, and what Li Zheng has to do is to let the risk assessment department of future generations evaluate it, and it will not be passed.
Since Mr. Yang slapped the table and patted a drug review system reform three years ago, he has almost always been there in the drug review committee. When his old man speaks eloquently, more than half of the key members will come to participate.
As long as Li Zheng can take advantage of the situation to convince them, then his HPV vaccine clinical trial is half successful.
Old Yang looked at Li Zheng with a complicated expression, "Li Xiaozi, do you really have such a high degree of certainty? This is no joke. The domestic clinical standard was established late, and the public's clinical understanding of this drug is not good enough. The acceptance level is not as good as in the West, and some people even regard this as a human experiment. If something goes wrong, no matter what kind of genius you are, the people will drown you with a sip of saliva."
Li Zheng is of course sure that the localization of the HPV vaccine was promoted by him, but due to the constraints of the 1990s, he could not explain all this with rigorous data.
"Old Yang, the HPV vaccine is not a biological vaccine, it is not a live vaccine or an attenuated vaccine, so it is very safe! And the HPV virus itself is not fatal, and its carcinogenicity is also a chronic process, so this time The clinical risk is far lower than you think."
"We know what's the use, the people only know that the virus is terrible, and cancer is deadly!" Mr. Yang said loudly.
There was silence in the room, and after a long time, Mr. Yang said again, "Tell me the truth, how sure are you."
"Nine percent."
"Jiucheng? Don't fool me!" Old Yang's eyes suddenly widened. He still admired Li Zheng very much. He knew that this biological genius was not a reckless person, so he thought to himself, if Li Zheng had If he was more than 70% sure, he would save face to help him.
But when the word "90%" came out of Li Zheng's mouth, Old Yang was hesitant.
Where did you get your confidence from? The international community has not yet recognized the carcinogenicity of HPV. You tell me now, you are 90% sure about the clinical medicine? Unless the drug has undergone a clinical trial, this is almost impossible.
This drug has really undergone clinical trials, more than once, but Li Zheng couldn't tell Old Yang like that, he could only express his seriousness and seriousness with a sullen face.
Mr. Yang stared at him for a long time, "Sure, I'll call you, but I insist on my point of view for the time being, and I suggest that the clinical trial be postponed."
When Li Zheng heard this, he was more moved than happy. He felt that he was very lucky. Whether it was in his previous life or in this life, the senior scholars he met spared no effort in supporting the juniors.
An old senior in the scientific research community of Huaguo said that the biggest feature of science is exploration and inheritance, and generations of scientists in Huaguo have also achieved this.
On the evening of April 28, 1990, it was a significant day in the history of the changes of the drug review system in Huaguo. On this evening, more than half of the members of the Huaguo Drug Review Committee gathered in the conference room of the Yanjing Hotel.
The night in Huajing in April was already two minutes of sultry heat, and the big electric fans were roaring. The Yanjing Hotel was rebuilt from an old Huajing guest house. This old brand means that the facilities are outdated. A group of bigwigs who play an important role in the Chinese medical industry sat together in twos and threes, discussing what happened to Yang Lao who came to them this evening.
When Lao Lao and Li Zheng arrived together, they were almost there.
"Mr. Yang, Professor Li, you are here." The speaker was a slightly chubby fat man in his early forties, wearing a pair of black-rimmed glasses, and smiling very kindly. There was a person next to him who also smiled and looked up to the two of them when he heard the words, it was Guo Kexuan.
"Old Yang, Professor Li." Guo Keke said.
"I'm really sorry for calling you here in such a hurry. But there is an injustice and a debt, and it delays your affairs. You can find him." Old Yang pointed at Li Zheng, "It's Professor Li who is looking for you for something. "Old Yang said with a smile.
Yang Laoming pushed Li Zheng out on the surface, but the intimacy inside and outside the words meant that those present, as long as they were not fools, could understand.
Naturally, everyone laughed at the face, and they didn't even delay.
After a few words of greetings, Li Zheng did not waste time, and waved the information in Zhang Chao's hand.
The HPV vaccine project was led by Li Zheng, with Liu Sichao and Zhang Chao assisting from the side. Li Zheng asked Zhang Chao to participate in the meeting together.
Some people in the drug review committee have heard of this HPV vaccine project. After all, Li Zheng has mentioned the drug clinical matter with the drug control department more than once, and the officials of the drug control department have naturally sought the opinions of several experts.
However, this detailed information is the first time I have seen it.
They turned around, and they started talking in twos and threes.
"The hepatitis B vaccine is clearly stated in the drug guide to prevent acute hepatitis. In this way, if Professor Li's HPV vaccine is really successful, and it is the first anti-cancer vaccine, it really lives up to its name."
"Cancer, just like our ancient people looked at smallpox and smelled it. Even if it is clear that it is a vaccine, it is very difficult to carry out clinical work."
"But if Professor Li really made it out, Huaguo took the lead in the clinical market, and this title may make a ring in the world."
"Cancer is the enemy of the entire human race. If the Chinese people can take the first step in defeating cancer, it will be of great significance."
"Who doesn't know, but we have to be practical, how to carry out the clinical trial work, and what if it fails? Although this HPV vaccine is not a biological vaccine, nor is it an attenuated vaccine, but to test whether it is effective, we must let volunteers Exposure to the virus, the HPV virus is also carcinogenic, how can this work be carried out?"
Everyone was talking a lot, but Li Zheng could hear it clearly beside him.
He coughed twice, and the amplification effect of the microphone made it clear to everyone present.
The meeting room gradually became quiet, and Li Zheng turned on the projector.
"This is the preparatory data for the three-point project. One is the data demonstration on the relationship between HPV virus and cervical cancer that can be found in the international shared data; the other is the data from Hong Kong Mary Hospital. Analysis of blood samples from cancer patients; thirdly, during the three-year project duration, Li Zheng's laboratory randomly selected 100 blood samples from cervical cancer patients of different ages, genders, and races."
"In the first data, the data of the paper that recognized the carcinogenicity of HPV showed that 70%-90% of cervical cancer patients had HPV virus subtypes in the blood samples. The second data was more accurate. In three years, there were 6729 cervical cancer patients in Queen Mary Hospital. HPV16 or HPV18 virus was found in the blood samples of 5621 patients. The third data was made by our laboratory in three years. Among 100 cervical cancer patients, HPV subtype virus was found in 76 blood samples. ."
"So, I myself have no doubts about the conclusion that the HPV virus is carcinogenic."
"Then the next step is the HPV vaccine. The principle of the HPV vaccine is to use a special protein antibody on cancer cells to trigger the body to produce immunity, so the HPV vaccine itself is a protein, not a virus. Simply inject the HPV vaccine. There is no virus infection."
When Li Zheng said this, he paused, looked around, and saw that everyone was listening carefully to what they said.
"In this clinical trial, the staff of Li Zheng's laboratory, including myself, and the management of Zhenzhe Laboratory said that we are willing to become the first batch of drug clinical volunteers."