"Xiangjiang is a big international city. Many friends from Vietnam, Laos, and Indonesia came here because of the relatively loose policies in the past two years. In the past ten years, the number of sick babies received by the orphanage in Xiangjiang has risen sharply, many of them Young children suffer from cryoemia."
Xu Mingsheng sighed when he said this, "Two days ago, we were invited to attend a seminar at Queen Mary Hospital, and we felt a lot. For such a soft child, their life has entered the countdown before it even started. , seeing these children lying motionless on the hospital bed, I really feel that we are not doing enough!"
"So, I discussed with Professor Wang and Professor Zhao, and planned to make an appeal at the meeting. I hope everyone can pay attention to this special disease and special medicine."
"The following are some materials and materials collected by Xiao Zhang. Let's talk about our opinions."
Li Zheng continued to scroll back. After the introduction about the cryoemia, there were pictures of some sick infants and young children. Their skin turned blue, their limbs and torso arched into a weird arc due to shrinkage. Xu Shi found that the camera was looking at them, the children and their bodies The big, uncoordinated head turned to look at the camera, and there was no hope for life in the big eyes.
Li Zheng's heart trembled.
Indeed, he did not do enough. How long has it been since I remembered my original intention of switching from molecular biology to pharmaceuticals? Li Zheng's fingertips slid across the child's eyes, and his eyelids were drooping, making it impossible to see his expression.
"Li Zheng, tell me what you think." Xu Mingsheng called Li Zheng's name.
Li Zheng put down the information in his hand and said, "Cryosemia is different from ALS. Its essence is a blood disease. The abnormal increase of coagulation molecules in the blood leads to an increase in blood density and gradual coagulation. According to the existing medical methods, Forcibly inhibiting the differentiation of blood coagulation molecules with amisatin is fatal for infants and young children under the age of two."
"The biggest obstacle to the development of this drug is the clinical four-drug trial, how to find so many sick infants to participate in the trial. Even if it is found, the infants themselves cannot sign a voluntary agreement for drug trials. The institution that developed this drug, in a From the very beginning, we have to take a huge risk of public opinion and politics. This appeal is not convincing enough."
Li Zheng's words were calm and cruel. Extremely low market expectations, huge public opinion and political risks can be labeled as immoral and human experiments at any time. In the face of these realistic conditions, this appeal seems a little thin.
Li Zheng's words were too sharp and realistic, and the office suddenly fell into silence.
Professor Zhao patted Li Zheng on the shoulder, "The problems that exist in reality are difficult to overcome, we can only do what we can do."
After leaving Xu Mingsheng's office, Li Zheng did not go back to the classroom or the hotel, but went to Jingyuan.
The current Jingyuan should be renamed Qingyuan, because Jingyuan's Jing is Shen Hongjing's Jing. This land was in Li Zheng's hands, so the name was naturally inappropriate.
But Li Zheng didn't want to take the time to think about the name, so he just removed the cursive prefix on Jing and changed his name to Qingyuan.
The engineering team sent by the Liang family moved very quickly. The outer walls of the five villas have been covered with stone materials, and the green garden is surrounded by high iron fences. The people sent by the security company are on duty 24 hours a day. Very high.
"How long will it take to complete?" Li Zheng asked.
The foreman smiled and said, "Don't worry, little boss. Butler Fang said that your equipment will arrive in a month and a half. We promise to tidy it up before your equipment arrives!"
A month and a half…
He can't wait another day!
Li Zheng called Zhou Sitian and told him that after going to Tokyo to attend an international conference in a few days, he immediately got into the laboratory.
Li Zheng asked Xu Mingsheng to borrow this laboratory. Not only did he borrow the laboratory, but he also borrowed two graduate students to help. One of them was the male student he saw this morning.
The male Xueba was also surprised to see Li Zheng. At noon today, he suddenly received a call from Dean Xu, asking him and his junior to go to the laboratory to help others.
Zhang Yuejun is naturally very happy to have this opportunity. Laboratories, like enterprises in society, have very clearly defined classes. At the top of the hierarchy is the head of the laboratory, that is, the actual owner of the laboratory, Xu Mingsheng, followed by several associate professor-level researchers, who can often independently preside over a project and have great autonomy.
Then there are the researchers who cannot independently lead the project, there are associate professors with less seniority, and there are lecturers who are working hard to climb the position of associate professor. In the end, it was them, these postgraduate experimental dogs.
And the experimental dogs are also divided into three, six, and nine grades. The first-class experimental dog can participate in a little project research. If the project host is happy, he can divide it into a corner and let you do it. That is the second work of iron and nails. Has gold content.
Second-class experimental dogs, commonly known as chores, have access to experimental equipment, and can perform some simple experimental operations at the request of the project host or first-class experimental dogs. Generally, it is repetitive work. Whether it can be mixed with three works depends on the project. The mood of the host.
Not to mention the third-class experimental dog, looking for information, looking for information, or looking for information. The only thing that can be won is the position of four and five works. It sounds good to say it, but in fact it has no gold content.
Zhang Yuejun is a first-class experimental dog, otherwise he would not be able to attend the Asian Biopharmaceutical Conference. And his younger brother Liu Menglin is a second-class experimental dog. He is already a graduate student. He has mixed two second papers, one is the second SCI paper and the other is an ordinary paper. In later generations, this result can be described as miserable. The age is pretty good.
But Zhang Yuejun didn't expect that he waited for all noon, and what he waited was not Professor XX, but Li Zheng.
A freshman
Are you kidding me? ! Zhang Yuejun couldn't help but curse his mother.
Li Zheng naturally saw what Zhang Yuejun and Liu Menglin were thinking. He walked into the laboratory, put on his shoe covers, took off his coat and hung it on a hanger, put on a lab-specific white lab coat, washed his hands, and put on rubber gloves, all in one go.
After changing into the familiar equipment, Li Zheng only felt refreshed for a while. He stretched his neck, then turned around and said to Zhang and Liu: "Introduce myself, my name is Li Zheng. A month and a half ago I published a paper on 'drug catalyst' in "Microbiology", and two weeks ago, I successfully extracted the drug catalyst in the public laboratory of Hong Kong University, and signed a patent licensing contract with two pharmaceutical companies. Three days ago, I used the drug The company paid the patent fee to buy Jingyuan, which is ten kilometers away from Hong Kong University, and used it as its own laboratory construction land.”
Li Zheng listed his deeds in such a high-profile manner, not to show off. But he understands the difference between a reluctant experimental dog and a motivated experimental dog.
Although the experimental dogs do some tedious chores and mindless repetitive work, it is undeniable that they save a lot of time for the project host. It is a well-established fact that in a laboratory, laboratory dogs are indispensable.
Zhang and Liu have big mouths, is it true? A freshman...
"I'm talking about the truth, you can ask Professor Xu for confirmation. You should know about the project I'm going to do now, Senior Zhang. We are very short on time. I hope the two seniors can help me as much as possible, and I promise to give the two The position of the second work." Li Zheng paused, "The second work of a substantial SCI paper."
Zhang and Liu were speechless. They knew that what Li Zheng said should be true. Xu Mingsheng was their mentor. Zhang Yuejun and Liu Menglin looked at Li Zheng, then looked at themselves, and suddenly felt that they had lived on a dog for so many years.
"Hey, wait, Li Zheng, I don't know what to call you, so I can just call you by your name. You said that I know the project, what project? I don't seem to know very well." Zhang Yuejun scratched his head and looked confused.
Li Zheng was dumbfounded, he took off a rubber glove, and took out the information about "freezing blood" in the morning from his bag.
"It's fine to just call me by my name. This is the information on 'freeze blood'. Professor Xu said that you collected it."
"Uh, yes." Zhang Yuejun nodded.
"That's it. The conference will be held on the 31st. We are going to leave on the 30th. There are less than five days left. I plan to do some preliminary work on the research on drugs for freezing blood." Li Zheng lowered his head and put on his gloves again.
Zhang Yuejun's expression was sluggish, and Liu Menglin was obviously still confused. He picked up the documents and flipped through them, then stared at Li Zheng with disbelief.
Just kidding!
According to a data provided by the Tufts Center for Drug Development and Research, the average cost of developing a new drug is about $2.6 billion, and the average development time is 7-11 years.
You saw a document this morning and told me at noon that you are going to study a new drug?
Li Zheng saw the suspicion in their eyes and rubbed his temples. He began to miss his research team.
"The death of cryoemia is due to the abnormal increase of blood coagulation molecules. Ammisatin is already available on the market to treat this condition, but amoxidine is not suitable for infants and young children under the age of two. But this at least shows that ammonia The ingredients of sardine can be used as a reference for the research and development of drugs for freezing blood, and our experiments are not clueless." Li Zheng explained patiently.
Seeing that the two of them were still in disbelief, he coughed dryly, "Of course, I won't let the two seniors help me, except for the second work I promised. When you help me in the laboratory, press Calculated by the hour, ten Hong Kong dollars per hour."
In the 1980s, when the average monthly salary in Xiangjiang was only 1,000 yuan, this was already a very high salary level.
Zhang Yuejun and Liu Menglin's eyes lit up, and they looked at each other, "How embarrassing this is. Professor Xu asked us to help you."
Li Zheng smiled, "You get paid according to your work, there's nothing to be ashamed of. I promise, this is a little secret between us. Professor Xu won't know about it."
Zhang Yuejun and Liu Menglin heard the words, and the smiles on their faces became a lot more real. Regardless of whether he is a daydream or not, they have the money to take it, and if he really succeeds in developing a new drug, he can still make a second game and make a steady profit.
So the two immediately said: "If you have anything, just tell me, we will do our best to help."
Li Zheng nodded with a smile, and immediately went to work.
"Liu Menglin, before 5 o'clock this afternoon, bring all the information on Amistatin to the laboratory, especially the report of its drug trial stage, find out!"
"Zhang Yuejun, repeat the production process of aminomethodin, record each step, increase or decrease the ingredients, and observe the reaction between it and thrombin!"
"it is good."
"it is good."
As expected of the experienced experimental dogs, Li Zheng's command made them quickly operate.
The author has something to say: Involving some professionals, based on strict principles, I bombed my little friend, Calvin... So it's a little short, tomorrow weekend, thick and long! !
There is indeed a prototype of the disease in this article, but I have done artistic processing, so there is no need to take a seat. There are also drug names and disease names, which are also processed~