"These groups of experiments are carried out simultaneously, pay attention to record the time." Li Zheng looked up at Zheng Lingling who came in wearing protective clothing, and nodded to her, "There are not so many protective clothing in the laboratory, let them not enter the room. No. 2 There are drinks and desserts in the refrigerator in the lab, and you can entertain your classmates.”
Speaking of food, Li Zheng unconsciously touched his stomach with his right hand, and Zhang Yuejun ran in before he could eat instant noodles yesterday. Yesterday's instant noodles are probably still on the table in No. 2 laboratory...
"Gululu~" The stomach made a very shameless sound.
Li Zheng's mouth pursed into a straight line.
Zheng Lingling looked at Li Zheng and said, "You didn't eat? Didn't eat dinner or didn't eat breakfast." She knew about Li Zheng's living habit.
Two days ago, she just asked the agency to send out the recruitment advertisement for auntie. She wanted to pick another two days, but looking at Li Zheng's current appearance, she felt that it would be better to lower the requirements and let the aunt join the job earlier.
Li Zheng was silent for a while, then Yu Guang swept over Zhang Yuejun, who kept recording data, and the little nurse who carefully classified the data, and said, "Ten minutes of rest, let's eat some bread to fill our stomach." He remembered that he still had enough in the refrigerator. Less bread.
After speaking, he took the lead and strode out of the laboratory.
"Li Zheng... Are you doing experiments? Researching new drugs?" Someone couldn't help but ask when Li Zheng came out.
Li Zheng smiled and shook his head, "It doesn't count. Laboratory No. 1, P3-level laboratory, is not open to the public during the project. If you are interested, you can visit the other laboratories." There is no sign of stagnation in the pace.
Li Zheng's polite attitude of alienation made everyone a little embarrassed. But Li Zheng didn't have the time to pay attention to the twists and turns in the children's hearts. After the experiment all night, his mood became more and more dignified.
Existing antibiotics let them try it out. In terms of the response of resistant bacteria to antibiotics, the most likely ones are Pseudomonas aeruginosa and Stenotrophomonas maltophilia.
If after 20 years, Li Zheng could say many treatment options with his eyes closed, such as aminoglycosides (amikacin) + cephalosporins (Supsen, ceftazidime) or quinolones (ciprofloxacin) Star) + third-generation cephalosporins (Supsen, ceftazidime), or ciprofloxacin + β-lactam enzyme-containing inhibitors (specialized star) and so on.
But now, in 1983, many of the drugs in these regimens were not yet on the market.
"Li Zheng, it's not good for you to stay in the laboratory all the time. Sometimes you only get inspiration when you go out for a walk. Going to the hospital as a volunteer is the practice of our medical school. You can go with us." The apple-faced girl Obviously not giving up.
Li Zheng took out the bread and milk from the refrigerator and distributed it to Zhang Yuejun and others, "No, my experiment is at a critical moment. Wang Jing, wait until you go back to the hospital next time, I need the patient's medication records and case conditions from last night. Also, I just wrote you several combination drug regimens on the white paper, you ask Professor Chen to try it, and tell me the patient's clinical response before noon."
"Zheng Lingling, let someone send a group of guinea pigs over, I'll be useful later."
"Okay." Wang Jing and Zheng Lingling nodded immediately. Wang Jing didn't stay too long. She said hello to Li Zheng, and ran out with milk and bread in her mouth. As a nurse, she knew that every second was right What does it mean to be a patient.
Li Zheng stuffed the last bite of bread, looked at the watch on his wrist, it took seven minutes, and it took ten minutes to walk back.
When the apple-faced girl saw that Li Zheng was about to leave within a few minutes, she couldn't help standing up anxiously. She reached out to grab Li Zheng's arm, but Zheng Lingling flexibly blocked it.
"Aren't you going to be volunteers? Hurry up. It's not too late for this kind of matter." The moment she stepped into the No. 1 laboratory, Zheng Lingling knew that she was in trouble this time. Well, she admitted that she was indeed a little proud, especially after the opening ceremony of Li Zheng's laboratory, the Governor of Hong Kong and the Governor's wife had a cordial conversation with her, and even her elders and relatives in her family were a little proud to talk about it. Feel.
This feeling of being affirmed as an individual rather than a family made Zheng Lingling a little swollen all of a sudden.
Although Li Zheng didn't tell her about what happened today, she could see the dissatisfaction in Senior Zhang's eyes. Zheng Lingling touched her nose. No, she had to make up for it.
"But… "
"There's nothing wrong with it. The student union is familiar with major hospitals, and I'll help you get in touch!"
Seeing Zheng Lingling's resolute attitude, the classmates didn't say much. When a group of people was walking out, they happened to see seven or eight professors from the medical school walking towards the green garden.
"Where's Li Zheng?" Professor Zhao asked directly when he saw Zheng Lingling.
Seeing the solemn expressions on the faces of the professors, Zheng Lingling couldn't help but sigh, "Li Zheng, he just entered the laboratory."
The classmates hurriedly said hello. Professor Zhao swept over the students, frowning into a Sichuan character, "What are you doing here, don't hinder Li Zheng from doing his business!"
Everyone, look at me, I look at you, and I can't speak.
The professors didn't pay any attention to what they were saying, and after getting the message that Li Zheng was in the No. 1 laboratory, they quickly walked to the laboratory.
When the professors arrived, Li Zheng and Zhang Yuejun were recording the reaction of the third group of drug-resistant bacteria. Looking at the newly released data, Li Zheng was 90% sure that the drug-resistant bacteria this time was Pseudomonas aeruginosa. bacteria.
Damn it! He thumped the table hard.
This is what Professor Zhao saw when he came in, and his heart suddenly lifted.
"How, is there any result?" The professors carefully put on protective clothing and walked into the laboratory.
Li Zheng didn't say much, and handed the data in his hand to Professor Zhao.
Professor Zhao's expression became more serious when he saw the experimental data. He presented the data to the professors for circulation.
After a long time, someone said with difficulty: "Are you sure it is a multi-drug resistant bacteria?"
Li Zheng nodded.
There is silence in the laboratory. The multi-drug resistant bacteria in the 1980s are also a well-known clinical problem in Western European and American countries with the most advanced medicine, let alone in Hong Kong.
As far as they know, among the existing antibiotics, it is difficult to find the existence of anti-Pseudomonas aeruginosa.
"I called Lao Chen in the morning. Lao Xu's high temperature was uncontrollable, and the wound was very inflamed. Lao Chen took three antibiotics at night, but there was no big reaction." Professor Wang's voice was very deep.
Although Xu Mingsheng is a little temperamental, he is very righteous. He fights for projects for the medical school. No one of the professors here has benefited from him.
Li Zheng's nails sank deep into his flesh. He took a deep breath and tried to make his brain function normally. There is still time, it is not over yet!
Yes, he still has time.
Pseudomonas aeruginosa is only sensitive to carbapenems, so he developed a carbapenem drug!
Carbapenem antibiotics are a class of β-lactam antibiotics modified from penicillin structure. There should already be carbapenem antibiotics developed by pharmaceutical companies, but they are still in the stage of secret testing and have not been promoted for clinical use.
Li Zheng focused on vaccines and cells in his previous life. He was not proficient in antibiotics, but fortunately, vaccinology had a lot in common with him, so that he would not become a headless fly.
Li Zheng remembers that carbapenem antibiotics include imipenem-cilastatin, panipenem, meropenem, etc. Among them, imipenem-cilastatin is the first carbapenem to be marketed Antibiotics, the rest are developed with reference to pressing Penem.
Li Zheng took out two penicillins from the experimental refrigerator. The structure of carbapenems is similar to the penicillin ring of penicillin, and he had to start from scratch.
"Professors, do you believe me?" Li Zheng suddenly asked.
The professors were startled for a while, and then they reacted. Professor Zhao said, "Do you have a solution?"
Li Zheng took out an appropriate amount of penicillin and poured it into the test tube, "Time is always passing by, you try hard to go this way, give it up passively or go this way, why don't you try it?"
Li Zheng said it was very easy, but it fell into the hearts of the professors like a big stone thrown into a calm lake. Yes, it is useless for them to be sad and annoyed here, why not try hard.
Their colleagues are still lying in hospital beds, and there are more than 100 lives, and the fate of more than 100 families and hundreds of people after these 100 deaths! What reason do they have for not trying hard!
The eyes of the professors became serious. At such an old age, their consciousness was not as good as that of a young man, and they couldn't help feeling a little embarrassed.
"Li Zheng, do you have eyes? To tell you the truth, we old guys don't have eyes at all. If you have eyes, don't have any scruples. Tell me at any time to fight, we are no worse than that guy!" Professor Zhao is very said boldly.
All the professors nodded their heads one after another. At their age, they had gained fame and status, and they didn't pay much attention to certain things. They didn't feel ashamed to beat a seventeen-year-old boy at all.
Hearing this, Li Zheng finally calmed down a bit. "I have a rough idea." After speaking, he drew the structure of the penicillium ring on the blackboard in the laboratory. Change the penicillium ring.
"Carbapenems, a whole new class of antibiotics."
Li Zheng's words were so powerful that everyone present stood still. Brand new antibiotics? Did they hear right?