"Teacher, I have extracted a brand-new antibiotic. The biological test is effective against Pseudomonas aeruginosa, but no one has tried it clinically."
There was a rustling voice in the ward. Xu Mingsheng was full of peach and plums all over the world. Although many of his students gave up the pharmaceutical industry, their basic professional skills were still there. Brand new antibiotics
Everyone's eyes couldn't help but fall on this famous "little brother".
Chen Sufen was stunned for a moment, then remembered what Wang Jing swore when she came back in the evening, and her heart couldn't help beating rapidly.
"A new antibiotic that is effective against Pseudomonas aeruginosa?" Chen Sufen almost trembled as she took the stack of documents in Li Zheng's hand, but as she read the data, the light in her eyes gradually dimmed.
Li Zheng's experimental data are really not good-looking. Just looking at these experimental data and judging by strict antibiotic experimental standards, the antibiotics Li Zheng extracted are too toxic and are not suitable for human clinical treatment at all.
"Thank you Xiaozheng, it's just that you carbapenem antibiotics still need to be improved." Even at this point, Chen Sufen still maintains the tolerance and gentleness of a high-end intellectual woman.
"Sister..." He thought about his words. If it were other people, since they themselves refused, Li Zheng would never say a word, but the person in front of him was Xu Mingsheng, the teacher he admitted.
"Teacher and wife, I'm 80% sure." Li Zheng said, this is the biggest guarantee he can do.
Due to its particularity in the pharmaceutical industry, neither doctors nor pharmacists will make any guarantees to patients or their families. The most they say is that I will do my best. Because the weight of life is too heavy for doctors or anyone to bear.
Such perfunctory remarks to patients or their family members are the protection of these practitioners for themselves. Since Li Zheng stepped into the field of biopharmaceuticals in his previous life, his mentors kept instilling this concept in him.
"I'm not 100% sure, absolutely don't make any guarantees to anyone!" These words were still in his ears, but Li Zheng still spoke, "The molecular structure of carbapenems is already very stable, and its nephrotoxicity can be completely aided by The most important thing is that Pseudomonas aeruginosa is sensitive to it. Teacher, I know that in your opinion, I may be experimenting with your life... But..." Li Zheng never Thinking of himself as a person who can talk, he can't even express himself well when it comes to excitement.
Sweat beaded slightly on his forehead. This pharmaceutical genius who has experienced two lifetimes and has been praised by many people on the high altar has completely lost his usual prudence, wisdom and calmness.
The professors couldn't help their eyes heat up. They fully understood how much risk Li Zheng took by saying these words.
Chen Sufen couldn't help but be moved. Her rationality as a doctor and her sensibility as a family member of a dying patient were in a fierce struggle in her heart. Her rationality and professional ethics told her that she must not be injected with drugs that failed clinical trials, but her Her husband is dying. Like those patients in the isolation room, after high temperature dehydration caused by drug-resistant strains, her internal organs fail. Her husband is running out of time!
Maybe... This so-called carbapenem can really work miracles!
Xu Mingsheng's consciousness was a little chaotic because of the high temperature, and his ears were buzzing. Although Chen Sufen didn't say it, Xu Mingsheng came out of the first-line clinical practice. How could he not be clear in his heart that so many antibiotics would be of no use at all. Is he infected with a drug-resistant strain, or a multi-drug resistant strain that is insensitive to all antibiotics on the market.
Facing the imminent death, Xu Mingsheng couldn't tell how he felt, perhaps because the fever was too high, he had no energy to think about it.
In a daze, he seemed to hear Li Zheng talking about drug-resistant strains and antibiotics, and Xu Mingsheng's spirit was lifted.
"Do you have the experimental data on drug-resistant strains? Show me!" Xu Mingsheng still remembered that he was only halfway done on the drug-resistant strains project. No, it should be said that the preliminary materials have just been prepared, and the preparations for the start of the experiment have been completed.
As soon as the excitement of the old man and scholar came up, he felt that his head, which was confused by the high fever, was also awake a lot, and he tried hard to stand up.
Seeing this, Xu Keqiang quickly took a cushion and placed it behind Xu Mingsheng.
He took the information from Li Zheng, "Old Chen, give me the glasses."
Chen Sufen glared at him, but still brought the glasses from the cabinet to Xu Mingsheng.
Xu Mingsheng turned page by page, sometimes stroking his palms and sometimes laughing, but he didn't know, others could hear how hard he was laughing, and Xu Keqiang and his disciples couldn't help but red-eyed.
After seeing the biological experimental data of carbapenem antibiotics on the last page, Xu Mingsheng was silent for a minute, then turned to look at Chen Sufen, "You have a clinical trial agreement, take a copy."
Chen Sufen's face changed greatly, "What are you crazy! Haven't you looked at the experimental data! Less than 30%, this does not meet the standard for human clinical trials! Even if you sign a clinical trial agreement, it is invalid!"
Yes, every stage of a drug trial has its criteria. In the biological experiment stage, if the experimental standard is not met on the animals such as mice, it cannot enter the next stage. Strictly speaking, a drug like Li Zheng with a survival rate of less than 30% of the guinea pigs entering the clinical stage of the human body is fundamentally a crime!
"Old Chen, don't forget who brought you out. My own body, I understand that the existing antibiotics are completely ineffective for me, and I can still speak to you with such a clear head, because You keep physical cooling 24 hours a day. But it’s useless, maybe in less than half a day, I will lose consciousness, and then my organs will slowly fail.”
Xu Mingsheng was very calm. He turned over the page with the experimental data printed on it, and wrote word by word in the blank space at the back:
"I, Xu Mingsheng, voluntarily accepted the injection of carbapenem antibiotics developed by Mr. Li Zheng, and I have fully understood the dangers of this test. All the consequences arising therefrom shall be borne by me, and no one is allowed to do any other form of pursuit.”
Inscription Xu Mingsheng, February 17, 1983.
"I don't agree! I don't agree! At least not now! I don't agree!" Chen Sufen couldn't help screaming when she saw Xu Mingsheng's actions. At this time, Professor Chen was completely a family member of a collapsed patient, "It can't be Now, not now!" she kept repeating.
Chen Sufen also understands that Li Zheng's antibiotics may be Xu Mingsheng's only hope, but the probability of this hope is too low. If he does not receive drug injections, maybe Xu Mingsheng has three or five days left, and maybe what miracles can happen in these three or five days
What she hopes is to wait a little longer, wait a little longer, although she does not know when it is appropriate, but now! She can't take it!
"Old Chen, as a biologist and the dean of the School of Medicine of Hong Kong University, I hope that even if I die, it will be dignified and valuable. There are still many infected people outside..." Xu Mingsheng's spirit returned after the excitement passed. All of a sudden weakened, and he was already struggling to speak.
"Why, why are you doing experiments for them, not them for you!" Chen Sufen finally said what was in her heart. As soon as the words came out, her face turned pale, she hid her face and went out. This proud Professor Chen understood that she Having lost her benevolence and work ethic as a healer, she needs to calm down.
"Li Zheng, right? I heard my dad mentioned you several times. I was not convinced at first, but it turns out that I am not as good as you. You..." Xu Keqiang was silent for two seconds, "Do you know Mr. Kent from MSD?"
Merck? A glimmer of light flashed in Li Zheng's eyes, and the American Merck was translated in the Chinese translation as Merck, Kent Blair, the chief person in charge of the New York laboratory under the name of Merck. He had dealt with that old man in his last life, a very cunning old fox.
"I don't know." Li Zheng remembered Xu Mingsheng's introduction to his son, a doctoral student at Harvard Medical School, and he vaguely had some guesses.
"Really..." Disappointment flashed across Xu Keqiang's face.
Kent Blair once gave a speech at Harvard. During the speech, he mentioned that a brand-new antibiotic has been born in Merck's New York laboratory. Of course, he only mentioned a little, but there were rumors in the Harvard Medical Laboratory, Antibiotic discovered at Merck's New York lab may be effective against Pseudomonas aeruginosa!
After learning that his father was infected with Pseudomonas aeruginosa, Xu Keqiang contacted his mentor immediately, hoping that he would get the drug that his father could use from Merck's New York laboratory.
But obviously his mentor didn't have such a big face for Mr. Kent to break the rules of the laboratory. He called Kent Blair countless times until Blair was turned off by his annoying phone. But from the irritable Blair's mouth, he heard a noun, carbapenem...
Therefore, when he heard the carbapenem antibiotics from Li Zheng's mouth, his whole body trembled with excitement.
"I will persuade my mother, and my father will ask you!" He also signed his name on the agreement written by Xu Mingsheng, and then bowed deeply to Li Zheng.
Li Zheng raised his eyebrows slightly, he nodded, and without talking nonsense, he took out a tube of reagents from the freezer incubator.
"Wang Jing, please come in with Professor Chen, and trouble her to prescribe medicines to protect the kidneys and relieve kidney toxicity."
"Hey!" Wang Jing responded crisply, and then quickly ran to the door of the ward.
But before she ran to the door, the door of the ward was pushed open, and Chen Sufen walked in from outside the ward with a calm expression holding a tray of medicines.
"No, I have prepared the medicine, let's start." She said calmly.
The dark red liquid slowly entered Xu Mingsheng's body along the transparent polyvinyl chloride tube. The people in the ward watched the liquid in Li Zheng's hands slowly being pushed out without blinking.
He put the discarded needles in the metal tray, then took a step back and said to Chen Sufen, "The kidney-protecting medicine will be injected after half an hour, and the oral poison-relieving medicine can be eaten now."
Chen Sufen nodded, since she had already started the experiment, she completely obeyed Li Zheng's orders.
After putting the oral medicine into Xu Mingsheng's mouth, Chen Sufen clenched his fists tightly, and even the sound of needles falling to the ground could be heard clearly in the ward.
twenty minutes later
"What's that red thing on the teacher's face?" a young man asked suddenly.
Chen Sufen rushed up and saw a red rash near Xu Mingsheng's ear. The rash was dense and there seemed to be liquid in it, so it was not scary.