The next day, inside the Central Continent Academy of Sciences-Shangdu Life Sciences Research Institute.
At about seven o'clock in the morning, five or six male and female employees were wiping tables and chairs in a conference hall and chatting about things on the Internet during their free time at work.
Because it was not yet time to go to work, the clear laughter of girls came from the venue from time to time, bringing a lively atmosphere to the quiet and solemn institute.
It wasn't until 7:30 that everyone wiped away the dust that had fallen in the venue and started wiping the windows and railings.
"Why aren't you done yet?"
At this moment, a middle-aged man in a straight suit rushed in with an urgent look on his face, "Hurry up, this venue will be used at eight o'clock!"
"Team leader, don't worry, the cleaning can be completed before eight o'clock." A young girl replied with a smile, "Why are you in such a hurry."
"What do you know?"
The middle-aged man looked even more anxious, "I just received news that the dean and deputy dean are coming to this meeting. Don't you know that the dean is accustomed to arriving ten minutes early?"
Everyone was startled and quickly accelerated their movements.
Just when the middle-aged man was anxious and even preparing to roll up his sleeves, there was a sudden sound of footsteps behind him.
The middle-aged man subconsciously turned around and saw a young man in a white shirt walking over, "Excuse me, is this conference room No. 3?"
"Yes, who are you?" The middle-aged man saw that the young man was a little unfamiliar, and realized that he was not from the hospital, so he subconsciously glanced at the work ID around the other man's neck.
Chen Chen
Never heard of it...
"I am the speaker of this meeting." The young man named Chen Chen glanced inside, "Can I go in now? I want to prepare in advance."
"Oh, okay, please come in..."
The middle-aged man quickly stepped aside and couldn't help but feel a little surprised when he saw the young man walking up to the podium skillfully and starting to adjust the projection equipment.
This was the first time he saw such a young face standing on that podium, not to mention, this time the dean was personally supporting him.
Everyone who was cleaning the venue looked at the young man curiously, and did not dare to continue chatting. They moved their hands a little faster, and the venue was cleaned up in about ten minutes.
The middle-aged man secretly breathed a sigh of relief. He took one last look at the podium and saw that the young man was still checking the PPT with a serious look on his face, so he gave a signal to everyone and prepared to leave the venue.
However, just when he was about to lead everyone away silently, his heart suddenly tightened.
In the corridor, I saw the dean and a large number of academicians walking towards here from a distance.
"Let's go!" The middle-aged man hurriedly yelled at everyone, and the group of people quickly left.
A few minutes later.
In the venue, a group of men wearing work clothes with different expressions filed in. Although the speeches had not yet begun, these people were still sitting quietly in their seats, showing excellent quality.
This group of people is not students, but a group of middle-aged and elderly people over fifty, and some even over sixty.
However, unlike ordinary middle-aged and elderly people, everyone here is at the top level in the academic world, and several of them are world-renowned figures.
These people are basically academicians of the Chinese Academy of Sciences, and several others are also senior managers like Wang Luo.
What Chen Chen has to do is to convince this group of top academic elites, because only if these people admit the feasibility of Chen Chen's plan can they give an official explanation and Professor Wang Xi will agree to go abroad for treatment.
Looking at the already full venue, Chen Chen bowed lightly and began to speak in a long voice:
"The so-called Alzheimer's disease is a devastating neurodegenerative disease that mostly affects middle-aged and elderly people. On average, there are 5 to 8 patients for every 100 people over 60 years old. With the aging of the world, As the epidemic worsens, this number is still rising exponentially.”
"Unfortunately, more than half of the people in the world do not know about this disease. Against the background of rapid medical advancement around the world, Alzheimer's disease has become the only disease with an increased mortality rate in the past decade."
As Chen Chen spread his hands, reports cut out from various newspapers and periodicals were continuously displayed on the big screen behind him.
The data in these reports are shocking.
"Alzheimer's disease, here I will call it AD for short, I believe some of you are already familiar with it. After all, there are only two main complications: Aβ protein deposition and Tau protein mutation."
"But it wasn't until we conducted an in-depth investigation that we discovered that the clues inside were extremely complicated. Behind the two complications were countless factors, just like endless threads tangled together..."
Chen Chen pointed to the screen behind him, "So far, the most in-depth discovery in academia is probably microglia. As a type of immune cells in the brain, experiments have proven that microglia can effectively phagocytose Aβ after being activated. protein and abnormal Tau protein, inhibit AD symptoms."
"But at the same time, this immune cell is a double-edged sword."
Chen Chen turned around, and several research reports were displayed on the screen behind him, "Recent research has shown that microglia not only engulf abnormal proteins, but they can also secrete a substance called apolipoprotein E, also known as ApoE. "
"The gene responsible for secreting ApoE has three structures, ApoE2, ApoE3 and ApoE4. This protein gene in each person's body is in pairs, and each person can only have one or two copies of them."
A list automatically appeared behind Chen Chen, "In other words, the chance of your genetic combination in each person's body is about one-sixth."
"ApoE originally helped clear Aβ deposition, but in subsequent studies, scientists found that E2 was more effective than E3, while E4 had the opposite effect and aggravated Aβ deposition."
"Having a copy of the E4 gene will increase the risk of AD by three times. If the gene sequence in your body is [E4E4], then congratulations, your risk of developing AD is 12 times that of ordinary people."
Following Chen Chen's words, there was a murmur of conversation in the audience.
"Microglia not only affect Aβ protein deposition, but also affect Tau protein mutations."
Chen Chen spread his hands, "The phosphorylation mutation of Tau protein will cause neurofibrillary tangles, leading to nerve cell death. But how does this death occur?"
"Current research results are that this death may still be caused by microglia. When it attacks those tangles, it will damage nearby neurons. At the same time, APOE4 secreted by microglia will also amplify the effect of Tau protein on Neuronal toxic effects.”
"So, after genetically identifying a patient, can we limit or activate microglia based on the patient's genes?"
Chen Chen followed the lead and said, "My Black Light Biological Research Center is based on this."
Several old men in the audience looked at each other and nodded approvingly.
Chen Chen uploaded the photo of the information in his hand to the projector, "AD complications always involve inflammation, and in recent research, people found that a kind of IL-1β cytokine can cause inflammatory reactions, and IL- The increase in 1β cytokines is due to the sharp decrease in TOM1 protein... "
“The paper published in PNAS confirmed this view. After the expression of TOM1 decreased, Aβ protein did increase in the brains of AD model mice, and the cognitive abilities of these mice also declined. "
"So, during my experiment, I used gene overexpression to activate the TOM1 protein gene, which greatly improved the condition of the experimental subjects."
Chen Chen passed the experimental materials up one by one, "You can imagine TOM1 as the brake structure of a car. In the brains of AD patients, this brake fails, and what we have to do is to repair this brake at the molecular level."
Everyone's expressions changed when they heard this.
"Through the first two methods, we have temporarily suppressed the disease of AD. However, if we do not find a solution, the result will still be a tragedy. Then what we have to do next is to eliminate the deposition."
"Therefore, the third project in our research center is Solaneuzumab, developed by Eli Lilly and Company. This is a monoclonal antibody targeting the Aβ peptide chain, preventing its deposition and aggregation, and eliminating it from the human brain."
"Of course, this is not enough, so we have the last and most important process - producing autologous neural stem cells through 'induced pluripotent stem cells' and activating G2 quiescent stem cells in the human brain."
"In this way, we can make the brains of AD patients recover again. Even if they cannot return to their original state, they can still recover to most of the extent."
Following Chen Chen's words, photos and evidence of animal experiments appeared on the screen, and everyone in the audience finally couldn't help it and started discussing in low voices.
"I will publish these results in "CELL" in the future. If you are interested, you can contact me and I can provide you with detailed data."
With that said, Chen Chen turned off the projector, turned around and walked off the podium.
Bang bang bang bang...
The crowd burst into applause.
Seeing this scene, Chen Chen couldn't help but think of the scene when Professor Wang Xi gave him a lecture.
More than a year ago, I was sitting in a university class, listening to Professor Wang Xi talk nonsense, and constantly instilling some forward-looking remarks to his students.
At that time, the lifelong goal of many people was probably to become an academic master like Professor Wang Xi in twenty or thirty years, right
But he didn't expect that just over a year later, he would be on an almost equal footing with Professor Wang Xi.
However, this is just the beginning...
Chen Chen thought silently.