Time is like a fleeting moment. Whether you are leisurely or busy, it can pass quickly without anyone noticing.
In the blink of an eye, the New Year has passed and time has arrived in the year 2221 of the Earth Federation.
Although school has not yet started, many postgraduate entrance examination candidates have already returned to school early.
The originally deserted campus became lively again with the return of students.
However, for the past month, Chen Chen and his trio have been in a state of confusion and have to work in the laboratory for more than ten hours every day.
I have breakfast at eight o'clock every morning and enter the laboratory at nine o'clock. In addition to leaving the laboratory for lunch at noon, it is already after nine o'clock in the evening when I come out again.
Sometimes they were too tired, so Chen Chen and Wang Wei would just spend the night in the lounge instead of going back to school.
Xia Yin's job is more logistical, such as buying food, delivering water, and taking care of experimental animals, which is much easier than the two of them.
Only three days before school started, the last batch of mice implanted with egg cells finally gave birth to cloned babies, and the preliminary work of the experiment was successfully completed.
So, Chen Chen divided the cloned mice into three groups.
The first group is the brain injury model group, and the group is divided into two teams: AB.
Among them, Team A will use artificially cultivated autologous stem cells for treatment, and Team B will use cloned autologous stem cells for treatment. The number of the two teams is four.
The second group is the spinal cord injury model group. Same as above, team A uses artificially cultivated autologous stem cells for treatment, and team B uses cloned autologous stem cells for treatment. There are four animals in each team.
The third group has the largest number, with a total of twenty, all of which are specially selected elderly SD rats. They are used for experiments on rebuilding the immune system.
All the mice in this group had been cloned and had their own cloned stem cells.
They will be treated with radiation and chemotherapy to kill most of the hematopoietic stem cells and mesenchymal stem cells in the body, and then injected with cloned stem cells to test whether they can regain their youth.
This is called a bone marrow transplant.
As for why there are so many third groups
That's because just the process of radiotherapy and chemotherapy can kill or injure most of these mice.
The so-called radiotherapy and chemotherapy are treatments that use rays and chemicals to kill cancer cell clusters at a certain location in the patient's body.
However, this treatment method has always been harmful to the enemy. After all, while killing cancer cells, the normal cells in the patient's body will also be overwhelmed.
This is why patients undergoing chemotherapy and radiotherapy lose their hair.
In fact, many patients with advanced cancer do not die from the spread of cancer cells, but from the chemotherapy process that destroys the patient's body, which has to be said to be a tragedy.
Since cancer was officially discovered in 1911, the war between humans and cancer has lasted for hundreds of years.
In this protracted war, mankind has been helpless against cancer, to the later emergence of radiotherapy and chemotherapy, and now to various targeted drugs, gradually regaining the lost position of life.
The advent of bone marrow transplantation as a treatment method marks the first victory in the war between humans and cancer.
This victory will continue to spread until one day in the future, mankind will completely defeat the disease of cancer and make cancer disappear from mankind.
Just like the smallpox back then.
Of course, not every bone marrow transplant is successful.
The bone marrow transplant method that is clinically recognized by the medical community today to treat leukemia has a success rate of only 60%.
And among these 60%, half of the patients will relapse after six months.
Therefore, bone marrow transplantation is still a journey full of thorns in the fight between humans and diseases.
If there is any improper operation in the middle link, resulting in the death of all these mice, it will mean that all the manpower and material resources in the past month have been wasted.
After all, even the main body is gone, what use are these corresponding cloned stem cells
Therefore, in order to accumulate experience in radiotherapy and chemotherapy on mice, Chen Chen deliberately used other mice to test the waters.
However, mice and humans are different after all. These chemotherapy methods are still too intense for mice, and Chen Chen can only guarantee a 40% survival rate.
However, with the birth of the last batch of cloned mouse cubs, the preliminary preparations for Chen Chen's three experiments were finally completed.
Next, is the formal experimental period.
Five more days have passed, and it’s officially the first day of school.
Chen Chen and the others submitted an application to postpone their return to school and continued to stay in the laboratory day and night.
At the same time, with the use of stem cells for treatment, both groups 1 and 2 began to show signs of recovery.
The third group was in a bad situation. Five of the twenty SD rats had died. Although the remaining rats were alive, they were also dying and no longer even eating.
Two days later, the chemotherapy was completely over. Some of the mice that were already dying were completely overwhelmed. Eight or nine died one after another, leaving only six alive.
But six is enough.
Chen Chen now only hopes that two or three of the six can survive until the end of the experiment.
In this tense atmosphere, another month and a half passed.
The three-month trial period that was planned has finally come to an end.
At this moment, the three of them were gathered together in front of a group of mice, with excitement on everyone's face.
"Final result verification..."
Chen Chen said to the recorder, "The number of the first group of brain injury model team A is 3, 3 are alive, and the degree of recovery: No. 1 is better, No. 2 is significantly better, No. 3 is slightly better..."
"The number of Team B in the first group of brain injury model group is 3, and 3 are alive. The degree of recovery: No. 1 is obviously improved, No. 2 is obviously improved, and No. 3 is obviously improved."
"Summary: The healing effect of Group A using artificial stem cells is obviously not as good as Group B using cloned autologous stem cells."
"The number of team A in the second spinal injury model group is 4...the number of team B is 4, the same as above. Regardless of recovery speed and effect: team A is not as good as team B."
"In the third set of experiments, 3 animals finally survived. Basic CT showed that all aspects of the body functions of the experimental subjects that were already in an aging state had been greatly enhanced... "
"I didn't expect that the three experiments were really successful!"
Wang Wei excitedly patted Chen Chen on the shoulder, "In other words, cloned young stem cells are far more effective than artificially cultivated autologous stem cells?"
"Moreover, the third set of experiments also shows that replacing bone marrow can really restore people's youth?"
Xia Yin also murmured in a low voice, with a look of disbelief on her face, "Chen Chen, we are going to be famous..."
Although Chen Chen also had a smile on his face, his eyes were very calm, "I will write two papers next. As I said before, Xia Yin is the first author, Viagra is the second author, and I am the corresponding author. Is there no problem?"
"No, I took advantage of you two. If it weren't for you, Chenzi, the experiment would never have gone so smoothly."
Wang Wei looked calm and suddenly asked, "By the way, why two articles? Isn't it three groups and three experiments?"
"One article is about the difference in the effects of artificially cultivated stem cells and cloned autologous stem cells on the human body. This article automatically covers the first and second sets of experiments."
Chen Chen explained, "The other article is about the bone marrow transplant experiment."
"Also, the first and second groups are more convincing when put together."
Xia Yin smiled and nodded, "What about the submission? It must be submitted to the first area, right?"
"Of course, the first of these two research results may be a bit doubtful, but the second one is definitely no problem if it is voted into the first district."
Hearing this, Xia Yin and Wang Wei cheered again.
"Then which journal do you plan to submit to?" Xia Yin asked.
"There are only a few top journals in the biological field, and of course I submitted it to Cell!"
Wang Wei was the first to answer, "Didn't your instructor teach you? The shorter the journal name, the better it will be!"
"Cell", also known as "Cell", is a magazine about the latest research findings in the field of life sciences. In the field of biology, it is undoubtedly the TOP of the TOP. The impact factor has not fallen out of the top three since its inception. It can be said that it is engaged in life sciences. The belief of professional people.
People engaged in scientific research often refer to "CNS papers". The CNS here is the abbreviation of the three top journals "Cell", "Nature" and "Science". No one will not be able to write papers in These three major journals are proud to publish papers.
Chen Chen looked at the extremely excited two people and said with a smile, "Viagra is right, he must have voted for "Cell". After all, it is faith."