"Nature" magazine published several papers on rapamycin in 2009.
Some scientists divided nearly 2,000 20-month-old mice, equivalent to 60 human years, into two groups. One group had rapamycin added to their food, and the other group did not.
The final experimental results were unexpected. The lifespan of the mice that took rapamycin was increased by an average of 14% compared to the other group.
In the last century, scientists have discovered two ways to extend the life of mammals. One is to "patch" genes, and the other is to control diet and reduce fat intake.
Needless to say, there is no need to elaborate on the method of repairing genes. That is something that Medpod3000 can only do.
The purpose of reducing fat intake is to reduce the activation of a protein molecule called TOR.
TOR is a signaling molecule originally secreted by the human body. It can regulate the growth of each cell of eukaryotic organisms. When TOR is activated, it will cause cells to synthesize biomolecules, increase cell mass, increase volume, and synthesize proteins and nucleic acids. Increase, promoting cells to become larger and heavier.
If a person is compared to a large, sophisticated machine, even if the energy source continues to absorb energy from the outside world, the various "parts" in the body will wear out over time, and the activation of TOR is like meeting the basic needs of life. Keeping the parts working extra overtime makes the machine age faster.
The reason why rapamycin can extend the lifespan of mice is probably because it "tricks" the mice's bodies into believing that fat intake has been reduced.
Of course, none of this is supported by any data from human clinical trials, and all applications for clinical trials using rapamycin to extend lifespan have been officially rejected.
Despite this, from 2010 to 2020, you can still hear rumors that many doctors secretly take rapamycin themselves.
However, after ten years, rapamycin, a "life-extending drug", overturned again.
The "Journal of Clinical Medicine" published a paper in April 2020, stating that low TOR activity will trigger the aging of the hematopoietic system.
In short, at the cellular level, inhibiting TOR can trick the body into slowing down aging, but in the hematopoietic system, TOR activity is needed to support itself.
Excessive inhibition of TOR will directly cause the aging of cell niches in the bone marrow, which in turn will trigger the functional aging of hematopoietic stem cells. It can be said that success or failure is a failure.
In fact, Chen Chen also considered improving rapamycin or using a combination of drugs to offset the side effects and find a specific drug to extend life.
But later Chen Chen discovered that in the field of stem cells, it could have a far greater effect on the human body and had greater potential than this drug, so he gave up rapamycin and switched to specializing in the field of stem cells, and finally developed a method to reverse aging. treatment program.
Now, in the face of immunosuppression, Chen Chen once again thought of this legendary drug, which can be regarded as a kind of historical review.
In the next half month, Chen Chen picked out a clone and gave it rapamycin, cyclosporine A and FK506 every day. The combined use of the three drugs soon completely reduced the clone's immune coefficient. Suppressed.
After the clone's immune system was suppressed, Little X extracted the clone and placed it on the stretcher again.
And this time, the clone was no longer injected with T-002, but T-003, which was improved again after two failures.
Compared with T-002, the T-003 virus is more complete, with two RNA errors knocked out, and it is more consistent with Chen Chen's genes.
Sure enough, when faced with T-003, this clone easily broke the previous clone's record of three hours and twenty-eight minutes, even though its immune system had been suppressed, and did not die for a full six hours after being injected with the virus.
Not only that, because the DNA in the clones is undergoing earth-shaking changes, Little Bad top.
In Chen Chen's eyes, the clone continued to expand almost as fast as a fermented steamed bun, and soon grew to a height of two meters. Its muscles were tangled, like a smaller tyrant.
This was the first time that Chen Chen and Xiao X had seen this situation.
However, the clone eventually died. His body still could not survive the transformation of the T virus. However, what is worth celebrating is that the clone actually persisted for a total of eight hours.
The extension of time gave Chen Chen new hope.
Looking at the clone that eventually turned into a zombie, Chen Chen looked thoughtful, "Although it still failed, this experiment is of great reference significance."
"Yes, there is no problem with our direction."
While controlling the Black Knight to collect the clone's DNA, Little There is no way to fight the T virus, and suppressing immunity will only make people die faster."
"However, if the T virus matches the host's DNA, it will be a completely different result."
As he said this, Xiao A mature clone is here, and it will take another six months for the new batch of clones to mature."
As he said this, Little
"It's normal."
Chen Chen nodded, "Just like a game, modifying a BUG will inevitably lead to a new BUG. Although the code can be continuously corrected to make the game close to perfection, as the game becomes more and more perfect, it will be more difficult to modify the BUG. It will inevitably increase, and these are all affecting the whole body... "
“So, it’s all about luck in the end?”
Xiao X asked.
Chen Chen nodded and sighed, "It's like the original ancestor virus was improved into the perfect T virus. There is an element of luck in it. And many special medicines in the world were not originally designed to target this disease. They are The appearance itself is a kind of luck.”
"It can even be said... that scientific research itself involves a certain amount of luck. This is unavoidable. However, the diligence and ability of scientific researchers can make up for this kind of luck."
"After all, luck will not always be on our side, but diligence and ability can..."
After thinking about it, Chen Chen added again, "Of course, money is also acceptable."
Little X: “…”