Sigh, the examination bed moved towards the ring magnet, Gu Jun remained motionless, relaxed his mind, and didn't think about anything, letting the equipment take pictures of his contrasting state first.
While the fmri machine was running, Professor Ma, Dr. Shen and others were looking at the images on several computer screens in front of the operating table in the front room.
At this time, the blood flow in Gu Jun's brain is displayed in the image, but only professionals can understand the meaning of the different colors and color brightness in different brain areas, as well as the parameters such as mr value, te value, t2 value, etc. disclosed information.
Not to mention Wu Shiyu, Cai Zixuan can only look at the picture and sigh.
"Ah Jun's state is normal." Dr. Shen told them.
After a while, after inputting enough image data of the control state, Professor Ma said to Gu Jun through the loudspeaker in the examination room: "Ah Jun, next we will do the stimulation task, from light to heavy. First, I will tell you about the abnormal things. Listen carefully. If you feel a headache, don’t hold it back, let us know the severity of your condition with your voice, and if you can’t bear it, tell me to stop immediately.”
"Okay." Gu Jun in the examination room responded, "Professor Ma, let's start."
With a calm middle-aged face, Professor Ma began to slowly name each name one by one: "Spell, deep diver, banyan disease, human banyan tree..."
Following Professor Ma's words, the brightness of the brain image on the screen suddenly increased, and the neurons in Gu Jun's brain became more active.
"Different scale disease, Ritual, Dagon, Tian Yiqing..." The more Professor Ma said, the brighter the color of the image, and the more nervous everyone became.
"Ah!" Gu Jun suddenly cried out in pain, he felt the dull pain in his head turn into bursts of severe pain, and his body began to stiffen a bit.
This is his stress state, and it is also the task state of this inspection. By subtracting the blood flow map of the task state from the blood flow map of the control state, the computer may discover the brain parts related to the unique mental operations in the task state, and now the instant comparison results are displayed on one screen.
Naturally, Dr. Shen could understand the images, so he frowned at the first glance, and said softly to Wu Shiyu and the two of them: "The blood flow in these three places, the frontal lobe, the amygdala, and the hippocampus, has all increased significantly."
Cai Zixuan couldn't help sighing immediately, and scratched his bald forehead, these three places are not a good thing...
He has read some research literature on ptsd. One of the main research results of ptsd brain imaging is to find that the patient's hippocampus and parahippocampal gyrus, amygdala, and prefrontal cortex have abnormal functions, so there is "prefrontal lobe-amygdala- Hippocampal circuit" pathological hypothesis.
That is, damage to the prefrontal cortex leads to weakened function, thus weakening the regulation and control of the amygdala, which makes the amygdala over-react to terrorism, and the damage to the hippocampus itself and the imbalance of the connection with the prefrontal cortex and amygdala are also involved. Impairment process on the patient's memory.
Now Hao Jun's blood flow measurement results are in line with the typical performance of this hypothesis in local brain activity.
The location of Haojun’s brain hemorrhage before was the right frontal lobe. If the injury and related surgery caused the abnormal function of the frontal lobe, then the cause could be found.
"Ah Jun, let's increase the stimulus now. Think back to what happened on that small island." Professor Ma said again, "If you can't stand it, stop, don't force it."
Gu Jun complied and completed this stimulating task. His head hurt so much that he could hardly bear it, and his breathing turned into panting.
Then came the heaviest task. The nurse next to the fmri machine gave him a document, which contained pictures of abnormal things such as dead bodies of deep divers and patients with the disease. Gu Jun only read two or three pictures, and his head was so painful that there were signs of involuntary muscle twitching before the seizure. He immediately closed his eyes and stopped.
And the stimulation task of this examination is over, but Gu Jun does not leave the examination bed for the time being, let the machine continue to record the changes in blood flow in his brain during the process of calming down.
On the other side, Professor Ma and Dr. Shen looked at the comparison images in the computer, their complexions became more and more ugly, and they were a little surprised...
When Gu Jun recalled traumatic scenes, the blood flow continued to increase; and when he watched stressful pictures, he experienced drastic changes in hemodynamics, not just in the three brain regions of the prefrontal cortex, amygdala and hippocampus, but The blood flow of the whole brain increased sharply, and this physiological response was much stronger than that of ordinary ptsd patients under stress.
Moreover, such rapid brain congestion is very dangerous, as it will lead to a sudden increase in blood pressure, and it is easy to rupture the microvessels in the brain and cause hemorrhage.
Considering that Gu Jun also has a history of cerebral hemorrhage and craniotomy, this level of stress is fatal to him.
"Not optimistic, really not optimistic..." Dr. Shen murmured, not a pessimistic person, but at this moment he felt helpless.
After Gu Jun came out of the examination room, as soon as he saw their expressions, he knew that the situation was not optimistic.
When he saw the results of those images, he was a little confused. Is the dysfunction caused by the frontal lobe damage? This is difficult to treat...
"Xian Jun." Wu Shiyu patted him on the shoulder, "You were still in a coma half a month ago, you will get better soon."
"En." Gu Jun nodded to her, and then said to Professor Ma: "Professor Ma, I want to do mri and mrs too, check it out."
MRI is nuclear magnetic resonance, which belongs to brain morphometry when used in brain function tests, and mrs belongs to in vivo magnetic resonance spectroscopy, which can measure the volume of the hippocampus and evaluate whether hippocampal neurons are lost or damaged. Because changes in the structure of the hippocampus are typical symptoms of ptsd patients.
To do these two kinds of examinations, radioactive substances, that is, contrast agents, are required to be administered first. Previously, due to concerns about side effects on his body, he did not use them easily.
Now it is Gu Jun's request, and Bold-FMRI cannot reveal the structure of his hippocampus. After discussing with Dr. Shen, Professor Ma and Dr. Shen agreed to carry out the examination, but let Gu Jun rest in the laboratory for three hours first. Then the nurse gave him a contrast agent, and then he completed the MRI and MRS examinations successively.
MRI is an anatomical image, while MRS records the synthesis of all chemical signals in the measured individual, and the measurement result is a spectrum of multiple spectral lines.
However, Gu Jun’s MRI images showed indirect signs of shrinking hippocampus—the temporal horn of his lateral ventricle was enlarged, and the shallow sulcus on the head of the hippocampus disappeared.
The mrs results also showed that his hippocampal neuron number had decreased signal.
On this day, Gu Jun also did some other tests, such as taking blood to measure the level of BDNF (brain-derived neurotrophic factor). The BDNF level of ptsd patients is usually lower than that of normal people. But now his bdnf level is low, and compared with the result of the last physical examination, it has dropped sharply.
Research data from the Bureau of Astronomy shows that the level of bdnf in people with high gnosis will be higher than that of normal people, which may also be the source of their gnosis.
Now it seems that Gu Jun has not only lost his high gnosis, but also has the neuroendocrine characteristics of ptsd pathology.
Putting all these test results together, Professor Ma and the others know what the answer is... Gu Jun's brain shape has indeed changed.
"Ah Jun, go back and have a good rest, relax, and don't think too much, we will discuss a treatment plan that suits you best." Dr. Shen pretended to be relaxed and comforted, and sent the three of Gu Jun out of the laboratory.
Then, Dr. Shen and Professor Ma came to the conference room next to them for a teleconference. Master Tong, Yao Shinian, and the director were all waiting for the inspection report.
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