At the Capital Institute of Biogenetics, Wang Haoyi was in his experimental office, reading the news about the Reedman virus, and thinking from time to time.
This human disaster has lasted for several months, and the severity of the disaster in the hardest-hit areas has reached unimaginable levels.
Unfortunately, his research field is to establish and optimize gene editing technology in hematopoietic stem cells and T cells, study the characteristics of related gene editing technology, and improve the efficiency and specificity of genes. The main areas he targets are genetic diseases.
This time, Reedman virus belongs to virology and is not that serious in China, so they don’t need to get close to it.
The virus has caused panic among the international community, but there is nothing he can do about it.
After reading the news, Wang Haoyi put down the newspaper and sighed. There is no use worrying about other things, do your own research and get to the point.
Bang bang! !
Just as Wang Haoyi was about to start studying his topic, an old man wearing glasses knocked on the door and walked up to him quickly, looking like he had something urgent to do.
"Director Liu, is there something urgent?"
"Academician Wang, the dean is here to inform you that Tangshan has made a breakthrough in the Reedman virus vaccine and is now conducting urgent technical research. Genomics experts are now needed."
Upon hearing this notice, Wang Haoyi stood up suddenly: "I'll go over."
Before Director Liu could speak again, Wang Haoyi had already started packing his things and preparing to leave the office.
…
Donghai Institute of Life Sciences.
The Yang Yun family quickly entered the laboratory. In the laboratory, there were members of their team, as well as students and assistants.
The key research and development plans of their team are precision medicine research projects, epigenomics detection technology and clinical applications, and new RNA methylation epitranscriptomic sequencing technologies. He is leading research on both projects.
The hot Reedmann virus outside belongs to immunology, but he is not an expert in immunology or virology, so he was not summoned by the medical team and continued to lead their research at the institute with peace of mind.
But just today, there was a notification from the capital that there was progress in the Reedman virus vaccine in Tangshan, and genomics experts were needed to participate in urgent technical research.
"Teacher Yang, what happened?" After standing still in the laboratory, other members and students looked at him, and a student asked.
"The capital needs gene editing and genomics manpower to carry out urgent technical research. Yu Jun, Mi Shuangli, you two come with me."
"Teacher Yang, can you tell me what technology it is?" a female researcher named Mi Shuangli asked.
"The ones at Tangshan Hospital in the capital are analyzing the genes of the Reedman virus vaccine."
"good."
The two nodded heavily and agreed without hesitation.
The Centers for Disease Control and Prevention issued a summons notice. Experts and academicians in genomics and bioinformatics who were leading research projects across the country did not hesitate to go to Tangshan Hospital in the capital to work on the project after receiving the news.
In just one day, nearly 20 genomics experts and researchers have arrived in Tangshan.
Personnel from the Centers for Disease Control and Prevention and the Ministry of Health knew the importance of this topic and coordinated, quickly mobilized experimental equipment and materials, and prepared experimental conditions for researchers.
Tangshan Research Institute.
Chen Mo, Wu Bing, and team members entered the conference room.
Several group members were surprised to see a room full of people. Some of them have been recognized, including the expert academicians of genetic immunology who are already in the medical team. There are thirty-three people present, including almost the top group of genomics expert academicians in the country, including their former mentors.
It can be said that a group of people with the most say in the field of genomics in China are all in this conference room.
They were looking at everyone, and the experts below were also looking at them. Many people couldn't help but marvel when they saw Chen Mo and Wu Bing leading the team, as well as the extremely young team behind them.
It is this young team that has made great achievements in two bioterrorism incidents, and this time it also made breakthrough progress even though they were not optimistic about it. Seeing that their students were among the team members, some academicians smiled with satisfaction. At least their students were making a difference, and they were very proud.
However, compared with Chen Mo who took the lead, all geniuses seemed to have become dim, and everyone's eyes quickly fell on Chen Mo.
In the past, I only heard its name but never saw its person, but today I finally saw it.
Chen Mo was also scanning the experts and researchers on the field.
Their team can also find poisonous proteins by themselves, but in order to speed up the process, the more people they have, the faster it will obviously be. This time, the Centers for Disease Control and Prevention and the Ministry of Health were coordinating, and the two institutions supported it. It was beyond his expectation to find so many researchers.
After distributing all the materials, Chen Mo walked to the podium in the conference room and went directly to the topic.
"This morning, we conducted another blood test on the patient, and you have the test results in your hands. The patient has regained preliminary consciousness, the antibody concentration in his body has increased compared with two days ago, and the number of viruses is decreasing. Theoretically, in another five days or so, the patient will be able to develop resistance to the Reedman virus."
After Chen Mo spoke, everyone listened carefully to Chen Mo's explanation. Many people on the field were old enough to be Chen Mo's teacher, but Chen Mo's performance was enough to be their teacher. It was under his leadership that the Reedmann virus vaccine achieved a breakthrough. No one dared to look down upon Chen Mo because of his age.
Many people were a little happy when they heard that the vaccine was effective, but they were interrupted by Chen Mo just as they were pleasantly surprised.
"But we detected two toxic proteins in the patient's body. These two toxic proteins increased as the concentration of antibodies increased. Just two hours ago, the patient died in pain, and less than five days later . He was not killed by the Reedman virus, but the poisonous protein in his body caused his death.
Our preliminary judgment is that this toxic protein is caused by the potential toxic protein gene in the vaccine platform system's mRNA. So next, your task is to find these two toxic protein genes in the vaccine. We will find ways to knock out these two genes and eliminate the toxicity of the vaccine. "
"Academician Chen, are there any drugs that can degrade these two toxic proteins to achieve the purpose of treatment?"
Hearing the following interruption to ask questions, Chen Mo nodded and replied: "We have thought about this method. The medical team is looking for drugs that degrade toxic proteins, but they have not been found so far, and they only treat the symptoms but not the root cause."
"Academician Chen, are these samples of toxic proteins?" Yang Yunjia, who was sitting in the first row, asked.
"Yes, we have isolated some samples from the patient's blood, but not many. After the project starts, samples of toxin proteins will be distributed to various laboratories. Next, I will explain to you the related characteristics of toxin proteins and mRNA. Relevant information. If you have any questions, you can stop and ask me, or ask Academician Wu, and we will try our best to answer them if conditions permit."
After the explanation, Chen Mo began to talk about some characteristics of poisonous proteins and information related to mRNA to facilitate their research.
(End of chapter)