Lu Jin came to his laboratory and extracted alleles from the DNA fragments of Qin Yaoguang and Wen Shouyi for verification and comparison. [www.aiyOushen.cOm]
According to common sense, the accuracy of DNA test for parent-child relationship can be 100% when the possibility of non-paternity relationship is excluded.
In other words, it is 100% accurate when it is determined that there is no blood relationship between two people.
But to confirm that there is a direct parent-child relationship between two people, the accuracy is only 99.99999%.
The nines after this decimal point can vary depending on how many alleles are intercepted.
However, under normal circumstances, when the accuracy of determining that two people have a direct parent-child relationship reaches 99.99%, it can basically be determined that the two people have a direct parent-child relationship.
The DNA that Lu Jin tested for Qin Yaoguang and Wen Shouyi was the complete sequence.
This is not only sequencing that ordinary people cannot afford, but even many people with millions of dollars may not be able to afford it. Of course, this is not a problem here in Lujin.
He tested the entire sequence, and the intercepted alleles were as diverse as possible. Therefore, the accuracy of the paternity relationship he tested was the highest, even if it was less than 100%.
Run electrophoresis before testing. Simply put, it allows the DNA double helix structure to "swim" under a certain voltage. DNA fragments with different functions "swim" at different speeds, so that different DNA fragments can be separated.
Alleles are then intercepted and analyzed and compared using software.
Lu Jin completed a complete set of procedures, and Gu Nianzhi watched with great interest.
Although she couldn't understand those pictures and data at all.
In order to strive for accuracy, Lu Jin spent half an hour using software to analyze and compare the intercepted allele fragments.
Finally, he sighed, "... They really have a biological mother-daughter relationship."
Gu Nianzhi: "..."
She was a little confused by the result.
She was mentally prepared, but when this prediction was confirmed, she felt incredible.
"...Qin Yaoguang and Wen Shouyi?! Are they really biological mother and daughter?!" Gu Nianzhi was extremely surprised, "Then it must be a surrogate pregnancy? But why did she put Wen Shouyi in the Qin's Orphanage? Later, she let Wen Dayou and his wife Adoption?!”
Lu Jin nodded, "Surrogacy is definitely the only explanation. But why Qin Yaoguang put Wen Shouyi in the orphanage? I can only ask Qin Yaoguang."
"... But do you think she will tell the truth?" Gu Nianzhi said quietly, his eyes bottomless.
Lu Jin said seriously: "She probably won't. But I think this is her **, do I have to ask?"
"Yes." Gu Nianzhi nodded cautiously, "This is related to the integrity of the evidence chain in the court. - Dad, you know Qin Yaoguang better. Can you reason why she did this?"
When Gu Nianzhi mentioned legal terminology, it was as if Gu Nianzhi's eyes were filled with circles when he heard the terminology of high-energy physics.
He said a little dazedly: "Actually, I don't know Qin Yaoguang very well. But I have worked with her on experiments for so many years, and I basically know her attitude towards genetic research."
"What's your attitude?" Gu Nianzhi asked quickly.
"Genetic research is one of her majors. She uses her own eggs to synthesize fertilized eggs and lets other women give birth to them as surrogates, just like catching a white mouse from a cage."
"Have you ever seen any experimenter pour out his feelings for a rat? Or treat the rat as a human being?"
Gu Nianzhi curled his lips and muttered, "I am also a guinea pig, but Qin Yaoguang uses me for experiments, so it would be better to throw me into an orphanage. - Why doesn't she use Wen Shouyi for experiments?"
Lu Jin felt a pain in his heart and didn't know how to comfort her.
In desperation, he subconsciously said: "... Maybe Wen Shouyi was the product of a failed experiment, so she was not used in the experiment."
Gu Nianzhi: "..."
Although I was not comforted, my mood miraculously improved. What a stupid thing...
Gu Nianzhi still kept a straight face and said seriously: "It seems that I am still valuable."
Lu Jin rubbed his hands in embarrassment and said as if begging for mercy: "... I think, dad knows he was wrong... "
Gu Nianzhi felt embarrassed, stepped forward and held Lu Jin's hand, pulled him to the sofa and sat down, saying, "Dad, I was just joking. But..."
She rolled her eyes, "You mean, Qin Yaoguang started doing embryonic genetic research long before I was born?"
This question can be answered.
Lu Jin said very academically: "I have no concrete evidence, but since Wen Shouyi was born using this method, Qin Yaoguang must have done research in this area."
"At that time, she didn't ask me for advice, so I didn't know that she had already been doing experiments in this area."
In other words, six years before Gu Nianzhi was born, Lu Jin knew nothing about Qin Yaoguang's secret experiment.
Gu Nianzhi nodded and continued to ask curiously: "But why would she use her own egg cells and Wen Dayou's sperm to make fertilized eggs and conceive embryos? I thought she would use other people's egg cells for research."
Lu Jin smiled and said lightly: "If she has already had such an experiment born, then it is definitely not the first time she has done this experiment, and it will not be the last one."
"What do you mean?" Gu Nianzhi's eyes suddenly lit up. "Could it be that she has done many research experiments in this area, even using other people's egg cells?"
"From a scientific experiment perspective, that's for sure."
Lu Jin patiently explained to her: "This kind of human embryo experiment requires a long cycle. It usually takes seven months at the earliest from fertilization to birth, that is, including premature babies."
"Normally it takes nine months, plus the preparations before and after, and the process of screening men and women for conception, one year has passed."
"When an experiment takes a year from preparation to result, the person doing the experiment will never do it one experiment at a time. Do you understand what I mean?"
Gu Nianzhi carefully digested Lu Jin's words in his mind. After a while, he said thoughtfully: "You mean, doing this kind of experiment is no different from doing other biological experiments. It requires a large number of experiments." , in order to filter out effective results.”
"She will prepare many such fertilized eggs, transplant them into the pregnant mother's belly at the same time, implant them in the bed, and then observe the results."
Lu Jin nodded heavily, "That's the truth. The failure rate of biological genetic experiments is actually quite high. Therefore, she needs to accumulate quantity and achieve qualitative change from quantitative change."
"And to do so many experiments, Qin Yaoguang definitely can't just use her own egg cells." Lu Jin used a popular science tone to spread common sense about egg cells to Gu Nianzhi.
"When females of all mammals are born, they already have immature egg cells in their ovaries."
"The number of egg cells in female animals is fixed at birth and will not increase, but will only gradually decrease."
"So it is impossible for Qin Yaoguang to only use her own egg cells to conduct such large-scale experiments. She must have used other people's egg cells."
Gu Nianzhi fully understood, covered his mouth with his hands, and gasped: "... Oh my God! How many embryo experiments did Qin Yaoguang do?! How many Wen Shouyi and Gu Nianzhi were born by her using this method?!"
Lu Jin smiled bitterly and said, "Nianzhi, do you really think this kind of experiment is easy to succeed?"
"Do you think it's grafting and raising seedlings?"
Gu Nianzhi: "..."
She really thinks so!
"Is it... harder?" Gu Nianzhi's thick, black and slender eyelashes fluttered, and her big eyes were full of curiosity.
"It's not harder, it's very difficult." Lu Jin didn't know how to explain it to Gu Nianzhi, "I just checked the full DNA sequence of Wen Shouyi, and I can see that Qin Yaoguang tried to gene edit her, but failed. "
Gu Nianzhi frowned, "That means she started gene editing the embryos before giving birth to me, or was it because of... Mr. He's disease?"
"I don't know if she let Wen Shouyi give birth because of He Chu's illness, but that might be the prototype of her idea. From that time on, she began to experiment with this method."
"But you have to know that human genes are very complex and huge. A few decades ago, our understanding of genes was not as comprehensive as it is now, and our instruments and techniques were not as advanced as they are now."
"In embryo experiments under those circumstances, very few fertilized eggs can successfully implant. It can be said that only one out of a thousand gene-edited fertilized eggs can successfully implant and impregnate the mother."
"And after these implanted fertilized eggs develop into embryos, only one in a hundred can successfully give birth."
Gu Nianzhi was very puzzled, "You mean those embryos that are pregnant will miscarry?"
"Of course. And the chance of miscarriage is very high." Lu Jin sighed, "Because these embryos have been genetically edited, many of them have genetic defects."
"The human body has a self-selection function. Embryos with genetic defects are called congenital defects and will naturally miscarry unless you use unconventional means to preserve the fetus."
"For scientific experiments, we will not preserve embryos with congenital defects, you know what I mean? - There are very, very few children who are actually successfully born and survive after gene editing. I very much doubt that in Among Qin Yaoguang's experiments, Wen Shouyi was probably the only embryo that was born and survived."
Gu Nianzhi nodded slowly, understanding a little more, but she had new questions.
"... You said that embryos that have been genetically edited have congenital genetic defects. Is this the same for me... and Wen Shouyi?"
Lu Jin shook his head first, then nodded and said, "You don't, but Wen Shouyi does."
Gu Nianzhi: "..."
"Why didn't I?" Gu Nianzhi was very suspicious, "Dad, don't say this just to comfort me."
"I'm not comforting you. You're questioning my professional ability!" Lu Jin's eyes widened, "... You did the gene editing myself!"
"My approach is completely different from Qin Yaoguang's. She disrupted the order of the original gene fragments and only cultivated He Zhichu's defective gene."
"On the basis of your original genes, I will exclude those non-human viral genes, and then use your own genes to expand and express them and then add them in."
"As a result, your genes have not been changed, but have been optimized to the greatest extent based on the original ones."
Lu Jin couldn't help but feel proud: "It turns out that I succeeded. You have the first set of perfect genes in human history! And this is without changing your original genes!"
Gu Nianzhi: "@_@".
She started to get mosquito repellent again.
She knew every word Lu Jin said, but she didn't understand them all together.
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This is the first update today: Chapter 1748 "Gene Optimization".
Two updates today.
Remind everyone of monthly tickets and recommended tickets.
Today is Monday, special recommendation ticket!
Second update at 8pm.
Hey guys, little angels~~~
╰(*°▽°*)╯[This chapter is first published. , please remember the URL ()]